Today, we shall be comparing and contrasting IVF, which is in vitro fertilization, with ICSI, ICSI or intracytoplasmic sperm injection. The first ICSI baby was presented to the world by professor Paul Devroy and professor Andre van Streatijim in 1992 in Belgium. Now in this class, we the learning objectives will be about physiology of fertilization, why there is failure, how is IVF different from natural cycle, and how is ICSI different from IVF? And finally, is there any evidence for using ICSI over IVF in non-male factor infertility? This is a very similar slide about physiology of fertilization. On the left side, you can see the normal process of fertilization, which involves sperm transport, capacitation or sperm activation, acrosome reaction or dissolution of the zona pellucida, and on the maternal side, on the woman's side, oocyte activation, which involves the calcium channels, and finally, phosphorylation. So all these things need to happen during the fertilization of the sperm with the oocyte. The capacitation and acrosome reaction occurs in the natural fertilization. The penetration of cumulus oophorus and zona pellucida. The zed p three glycoprotein requires activation of signaling pathways, and this is known as capacitation. In turn, capacitation is necessary for acrosome reaction. So these steps imply further selective pressure on the sperms. So it follows that those sperms that lack the signaling mechanisms cannot or do not reach the oocyte in natural fertilization. Again, it is the selection of the fittest in the sense those sperms that are capable of having these signaling mechanisms are the ones that reach the oocyte. Visit: https://www.iirrh.org/fellowship-in-reproductive-medicine.php

What is React Native 0.79? Speed Boosts & Debugging Upgrades React Native is a tool used to make mobile apps. The new version – React Native 0.79 – is here! This update helps apps run faster and makes it easier for developers to fix problems (bugs). In this blog, you will learn what’s new in this version and how it helps in building better apps. 🔗 Read More: https://moonstack.co/what-is-react-native-0-79-speed-boosts-debugging-upgrades At Moonstack, we use the latest tools like React Native 0.79 to build smart and fast mobile apps. Want to make an app or improve your current one? We are here to help you! Let’s connect : https://moonstack.co/

Caring for the Natural Elegance of Travertine Floors Travertine floors exude a timeless elegance, bringing a touch of nature's artistry into interior and exterior spaces. Characterized by its unique pitted and textured surface, and often showcasing beautiful variations in color and veining, travertine offers a warm and inviting ambiance. However, like any natural stone, travertine requires proper care and cleaning to maintain its beauty and longevity. Understanding the specific needs of this material is paramount to preventing damage and ensuring its enduring appeal. The very characteristics that make travertine so distinctive also dictate how it should be cleaned. Its porous nature means it is more susceptible to staining and scratching than some other flooring options. The naturally occurring holes and crevices can trap dirt, dust, and spills, making regular and thorough cleaning essential. Ignoring routine maintenance can lead to a buildup of grime that is difficult to remove and can dull the stone's natural luster. Daily care for travertine floors is a simple yet crucial step in preserving their pristine condition. Regular sweeping or vacuuming with a soft brush attachment is recommended to remove loose debris such as dust, dirt, and pet hair. These small particles, if left unattended, can act like abrasives underfoot, gradually scratching the surface of the travertine over time. It is important to use a vacuum cleaner without a beater bar, as this can also cause scratches. For areas with heavy foot traffic, more frequent sweeping or vacuuming may be necessary to prevent the accumulation of dirt. While daily dry cleaning addresses loose debris, periodic wet cleaning is necessary to remove more ingrained dirt and spills. When it comes to washing travertine floors, the choice of cleaning solutions is critical. Harsh chemicals, such as bleach or ammonia-based cleaners, should be strictly avoided. These substances can react with the minerals in the travertine, leading to discoloration, etching, and weakening of the stone's structure. Similarly, acidic cleaners, including vinegar or lemon juice, can damage the calcium carbonate composition of travertine, causing irreversible etching and a loss of shine. The ideal cleaning solution for travertine is a pH-neutral stone cleaner specifically formulated for natural stone. These cleaners are designed to be gentle yet effective at removing dirt and grime without harming the stone's surface. When using a stone cleaner, always follow the manufacturer's instructions for dilution and application. Typically, a small amount of cleaner is mixed with warm water. The process of wet cleaning travertine floors should be approached with care. Use a clean mop made of microfiber or other non-abrasive material. Avoid using string mops, as they can trap dirt and potentially scratch the surface. Dip the mop into the cleaning solution, wring it out thoroughly to prevent excess water from seeping into the porous stone, and then gently mop the floor in overlapping strokes. Rinse the mop frequently in clean water to avoid spreading dirty water across the floor. After mopping, it is essential to dry the travertine floor thoroughly with a clean, soft cloth or towel. Allowing water to sit on the surface can lead to water spots and potentially penetrate the stone, causing staining or damage over time. Pay particular attention to grout lines, as they can also absorb moisture and become discolored if not properly dried. Beyond regular cleaning, occasional deep cleaning may be necessary to address stubborn stains or buildup. For light stains, a paste made of baking soda and water can sometimes be effective. Apply the paste to the stain, allow it to sit for a short period, and then gently wipe it away with a damp cloth. Rinse the area thoroughly with clean water and dry it. For more persistent stains, it is advisable to consult a professional stone restoration specialist who has the expertise and appropriate cleaning solutions to address the issue without damaging the travertine. Protecting travertine floors from spills is another key aspect of their care. Because of their porosity, travertine can readily absorb liquids, which can lead to staining. Promptly wiping up any spills, especially those from acidic substances like wine, coffee, or juice, is crucial. Use a clean, absorbent cloth to blot the spill immediately. Avoid rubbing, as this can spread the stain. https://greencarpetclean.ie/services/hard-floor-cleaning/travertine-cleaning/

How Cricket Betting Odds Shape the Game for Punters Worldwide Across the globe, millions of fans dive into cricket betting with enthusiasm, and at the heart of it all lie the cricket betting odds. These odds not only guide where the smart money goes but also reflect real-time insights into team form, pitch conditions, and public sentiment. Bookmakers adjust the odds constantly, reacting to changes such as player injuries, toss results, and match-day weather. Web:- https://www.cricketbettingreviews.com/ #cricketbettingodds, #minesgame

Can The Asthma Clinic In Fresno Treat Allergies? Food Allergy Skin Testing helps identify food allergens triggering allergic reactions, allowing for the development of specific treatments. It also helps identify asthma causes and triggers, promoting healthy lifestyle choices. Fresno-based allergists can detect allergens and asthma-exacerbating factors, allowing for better dietary control and treatment. Respiratory allergy testing diagnoses respiratory conditions caused by airborne substances, even if they cause obtrusive health states. Please read our blog to learn more about The Asthma Clinic In Fresno Treat Allergies: https://premiumallergy.blogspot.com/2025/04/can-asthma-clinic-in-fresno-treat.html #allergyclinicfresno #asthmaclinicfresno #fresnoallergist #fresnoallergytesting #fresnoallergytreatment #fresnopediatricallergist #fresnoallergymanagement #pediatricallergistfresno

#Elemental_fluorine (F₂) is a pale yellow, highly toxic, and extremely reactive gas, used in chemical manufacturing and nuclear processing due to its strong oxidizing properties. https://wemarketresearch.com/reports/elemental-fluorine-market/1536 #F2Gas #ReactiveElement #ToxicGas #Halogen #OxidizingAgent #Chemistry #IndustrialChemicals #ChemicalReactions #NuclearProcessing #FluorineUses

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Polymerase Chain Reaction (PCR) Technique For DNA Sequence Learn about the Polymerase Chain Reaction (PCR) technique and discover its role in DNA amplification genetic research. Discover More: https://rb.gy/0nmwv7 #genetictesting #genetic #polymerasechainreaction #pcr #dnasequence #dnaamplification #healthcare

RAM Programs vs. Reactive Maintenance: Why Planning Ahead Pays Off When it comes to roof care, the choice between RAM Programs vs Reactive Maintenance can significantly impact the longevity and performance of your roof. At Tectum Roofing, our Roof Asset Management (RAM) Program provides property owners in Colorado Springs with a proactive approach to roof care. Visit here: https://weroof.com/blog/ram-programs-vs-reactive-maintenance/

If you're wondering what are the things to avoid after IUI, you're not alone. Many hopeful parents are eager to give their best shot at conception after undergoing Intrauterine Insemination (IUI). While the procedure itself is quite simple and quick, the post-IUI phase is equally important. Certain habits and lifestyle choices can affect the success of the treatment, and knowing what to avoid can increase your chances of a positive outcome. First and foremost, avoid heavy lifting or strenuous physical activity for at least a few days after the procedure. Gentle walking is encouraged, but intense workouts, heavy gym sessions, or any movement that strains the abdominal area should be avoided. Stress is another major factor; emotional stress can influence hormonal balance, so it's crucial to remain as calm and relaxed as possible. Deep breathing, meditation, or engaging in relaxing hobbies can be helpful. Avoid smoking and alcohol completely. These substances can negatively impact implantation and early pregnancy. Also, stay away from hot baths, saunas, or anything that could elevate body temperature significantly. Over-the-counter medications and herbal supplements should only be taken with your fertility specialist’s approval, as some ingredients might interfere with the process. In addition, avoid obsessively testing for pregnancy or constantly checking symptoms. Give your body time to respond naturally and follow your doctor’s timeline for testing. Lastly, avoid comparing your journey with others. Everyone’s body reacts differently, and patience is key. Taking simple precautions and focusing on a healthy lifestyle can make a big difference in your IUI journey. Always communicate openly with your fertility specialist for personalized advice and support. https://omyafertility.com/blog/what-are-the-things-to-avoid-after-iui/