Pregnancy is a complicated biological phenomenon that relies on a fine line between the immune system of the mother and the growing embryo. Although the main task of the immune system is to defend the body against foreign invaders, in another case, it can incorrectly identify the embryo as a foreign agent and act in response in a way that leads to loss of the pregnancy due to immune reasons.

This is a less-known cause of miscarriage, a topic of intense research in the field of reproductive immunology. This developing field examines the effect of the immune system on fertility and pregnancy outcomes. When you have had recurrent miscarriages, or you have experienced infertility of unknown causes, then it is time to focus beyond the conventional diagnosis. We provide state-of-the-art infertility treatment in Delhi at Sehgal Nursing Home, and we also evaluate and treat immune-related pregnancy loss.

What Is Immune-Related Pregnancy Loss?

Immune pregnancy loss is a situation in which the mother has an immune system that does not accept the embryo, and the system rejects it or does not implant it. This may occur either as a result of:

• Autoimmune reactions - the immune system will attack the tissues of the body, including the placenta or embryo.

• Alloimmune responses- the inability of the immune system to respond adequately to the foreign genetic material of the father.

These two routes are capable of causing inflammation, impairing the activity of the placenta, and undermining embryo development, resulting in an early loss of pregnancy.

Common Immunological Factors Linked to Miscarriage

Among the major immunological causes, we could list:

• Antiphospholipid Syndrome (APS): A disease in which the antibodies are directed against the phospholipids, which put a person at risk of clotting and insufficiency of the placenta.

• Increase in Natural Killer (NK) Cells: A hyperactive NK cell may destroy the embryo or interfere with the implantation.

• Th1/Th2 Imbalance: The excess of activated Th1 (pro-inflammatory) may disrupt the acceptance of an embryo.

• Autoimmune thyroid diseases: Autoimmune diseases such as Hashimoto thyroiditis may establish an inflammatory microenvironment that is unfavorable to pregnancy.

The knowledge of these immune dysfunctions is essential to make precise diagnosis and effective planning of pregnancy.

How Is Immune-Related Pregnancy Loss Diagnosed?

In Sehgal Nursing Home, we have a team of professionals dealing with fertility care, including a complete diagnostic assessment that can comprise:

• Antiphospholipid antibodies, ANA, and thyroid antibodies blood tests

• Testing of Uterine NK cell activity

• Th1 /Th2 ratio Cytokine profiling

• Recurrent miscarriage genetic testing

The tests aid in the detection of hidden immune problems that are usually overlooked during the general fertility assessment.

Available Infertility Treatment in Delhi for Immune Causes

In the event that immune-related pregnancy loss is detected, therapy aims at the immune system balancing to achieve implantation and pregnancy maintenance. The usual solutions are:

• Low-Dose Steroids (Prednisone): It is used to curb the hyperactive immune systems.

• Intralipid or IVIG Therapy: It assists in regulating the NK cells and lessening the inflammation.

• Heparin and Aspirin Therapy: A common combination in APS whereby they are utilized to prevent clotting and enhance the functioning of the placenta.

• Paternal lymphocytes immunotherapy (experimental in India): A potential method of regulating maternal reaction to fetal cells.

• Stress management and lifestyle changes are also known to influence immune regulation.

Assigning an appropriate infertility treatment in Delhi is subject to an expert team that is conversant with the dynamics of reproductive immunology. At Sehgal Nursing Home, we establish a personalized treatment program depending on your medical records, test findings, and reproductive desires.

Suggest to Read :- IUI & Pregnancy: Process, Success Rates & What To Expect

When Should You Suspect an Immune-Related Cause?

Immune testing and a visit to a reproductive immunologist may be options to consider should you:

• Made two or more miscarriages in a row

• Be exposed to IVF failure that is unexplainable

• Suffer/have had a history of autoimmune diseases (such as lupus or thyroiditis)

• Experience infertility for unknown reasons even though reproductive testing is routine.

The Hope That Science Offers

Reproductive immunology is changing our perception of fertility problems. Scores of couples who used to experience recurrent pregnancy losses with no solution are now getting hope due to immunological assessment and specific treatment. Successful pregnancy is no longer a far-fetched idea with early diagnosis and appropriate medical help. Indeed, the possibility is even more likely.

Trust Sehgal Nursing Home for Advanced Fertility Solutions

Sehgal Nursing Home does not stick to the traditional ways. Being the pioneers of infertility care in Delhi, we combine the use of modern diagnostics and the best practices of care to help solve even the most complicated fertility problems, such as immune-related miscarriages. Our skilled professionals will do their best to make your future and your pregnancy healthy.